COLUMBIA, S.C. (AP) — Trevor Lawrence threw for 295 yards and three touchdowns to lead No. 3 Clemson to its 27th straight victory and second consecutive 12-0 regular season with a 38-3 victory over rival South Carolina on Saturday.

Travis Etienne ran for two touchdowns to break Atlantic Coast Conference marks for career touchdowns (57) and rushing scores (53) as the Tigers dominated throughout on the way to a sixth straight win over South Carolina (4-8).

Lawrence had touchdown throws of 10 and 65 yards to Tee Higgins and of 16 yards to Justyn Ross. He completed 25 of 35 throws — tying an Atlantic Coast Conference single-game mark with 18 straight at one point — before coming out in the fourth quarter.

Lawrence also had 66 yards rushing to lead Clemson (No. 3 CFP), which will attempt to become the first program to win five straight league championship games when it meets Virginia next week in Charlotte, North Carolina.

Clemson’s defense did its part in the beatdown, holding the Gamecocks to 174 yards and continuing a run where the Tigers have limited all 12 opponents this year to less than 300 yards of total offense.

South Carolina’s defense showed some fight very early, stuffing Etienne for no gain on fourth-and-goal at the 1 on Clemson’s first drive. Four plays later, though, Ryan Hilinski threw an interception to Derion Kendrick to set up the first score and Clemson’s rout was on.

Lawrence connected with Higgins on a 10-yard score on a perfectly placed over the shoulder throw.

Higgins was on the other end of another beautiful Lawrence TD pass from 65-yards out.

Lawrence and the Tigers benefited from a couple of official reviews. On the first, Justyn Ross’ 33-yard catch after he was pushed out of bounds and returned was upheld when South Carolina challenged the call. Then Ross’ catch, initially ruled caught out of bounds, was overturned for a 16-yard scoring pass as his backfoot touched turf before going out.

South Carolina, which gained 600 yards a year ago in this game, struggled to make anything against Clemson’s front-line defense. The Gamecocks finished with 99 yards overall the first 30 minutes and their only score was Parker White’s 39-yard field in the second quarter.

It was South Carolina’s fewest points scored against Clemson in 30 years since a 45-0 shutout loss in 1989.